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Acute problems such as severe burns, dehydration, vomiting, diarrhea, high fever, severe infection, severe heart failure symptoms or severe breathing problems can make your body more sensitive to metformin and increase your chances for the side effect of lactic acidosis. Mascitelli and colleagues raise the interesting possibility that metformin may enhance insulin sensitivity by inhibiting intestinal absorption of iron. This is not a known effect of metformin, and the hypothesis warrants testing. I pray that my 'GOLDEN TICKET' Will be Femara, Ovidrel, TI + Prog Supps. I am very hopefull that I can get pregnant this way with just TI. J Holte, G Gennarelli, L Wide, H Lithell, C Berne. High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 83: 4(APR 1998):1143-1150. Since then, more clinical studies have been conducted. The results are contradictory. From almost no effect, to very positive effects. As the situation is right now, we can'T give any recommendations regarding metformin and PCOS, but check with your doctor for the latest scientific reviews.
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